UF Center for Natural Products

Decoding the Genes Behind Dolastatin 10 Paves the Way for New Cancer Therapeutics

Researchers at the University of Florida College of Pharmacy have identified the genes responsible for the creation of dolastatin 10, a marine natural product that has led to six FDA-approved cancer drugs since 2011. The research team used genomic library screening and genome sequencing to identify the genes responsible for producing the marine natural product.