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Community Calendar for Entrepreneurs

BIO 2025: Technologies Available for Licensing

Contents

The following technologies are the newest among University of Florida technologies handpicked for companies meeting with UF Innovate staff at BIO International 2025. Each category and specific technology available for licensing is linked to a (slightly) more detailed description below.

AG BIOTECH

AI/DIGITAL BIOTECH

CELL & GENE THERAPY

CNS, NEUROLOGICAL DISEASE

ENZYMES & MISCELLANEOUS

IMMUNOTHERAPY

INFECTIOUS DISEASE

MEDICAL DEVICES

MICROBIOME

ONCOLOGY

PAIN, INFLAMMATION

RNA THERAPEUTICS

VETERINARY

AG BIOTECH

The Actinobacteria Strains at NPDC as Biological Materials

S-T00393

  • Natural products
  • Success in the history of drug discovery
  • UF Scripps
  • 122,550 strains

Engineering And Use of Methylated Variants of Plastoquinone as Synthetic Inhibitors of Photosynthesis

T19050

  • Acute toxicity for plants and cyanobacteria
  • New class of herbicides
  • PCT filed

Bacterial Pesticidal Protein Toxic to Asian Citrus Psyllid

T19240

  • Huanglongbing or citrus greening disease
  • Bacillus thuringiensis (Bt)
  • Asian citrus psyllid
  • PCT filed

Bacterial Pesticidal Proteins Active Against Small Hive Beetle

T19252

  • Small hive beetle (SHB, Aethina tumida)
  • European honey bee
  • Pesticidal proteins derived from  Bacillus thuringiensis
  • PCT filed

Bacterial Pesticidal Proteins Toxic to Whitefly

T19281

  • Toxic protein to whitefly
  • Bacterial pesticidal proteins,  Tpp78Aa1, Tpp78Ba1, and Cry1Ca
  • PCT filed

Embedded Printing of Thick-Structured Meat Constructs

T19439

  • Scalable 3-D printing that mimics meat texture
  • Prints muscle and fat structures
  • Perfusable channels support growth and maturation of cell structures
  • PROV filed

UF Golden Tomato Engineered for Increased Beta-Carotene in Fruit and Improved Nutritional Value

T19447

  • Transgenic tomato plant
  • Increase beta-carotene and Vitamin A content
  • Golden color with high beta carotene content
  • PROV filed

Transgenic Plant and Methods of Stimulating Nickel Hyperaccumulation in Plants

T19535

  • Nickel mining using plant
  • NixA Nickel Permease gene to update Ni and Histidine gene to make it tolerable
  • PROV filed

In ovo Vaccination of Genetically Modified Salmonella Vectored Vaccines

T19642

  • In ovo vaccination of 18-day-old chicken embryos
  • Genetically modified self-destructing Salmonella vectored Vaccines
  • bacterial, viral and parasite pathogens
  • PROV filed

Engineering Electron Transport Chain for Increased Chemical Production in E. coli

T19676

  • Completed redesigned electron transport chain for ATP generation
  • 50% more ATP production/level
  • Commercial product synthesis
  • PROV being filed

Control of Male Fertility in Crops

T19696

  • SlUGT78D-B disruption
  • Male infertility in crops
  • PROV being filed

A Real-Time Computer Vision and RFID-Based Dairy Cattle High-Throughput Phenotyping System

T19702

  • Dairy industry focus
  • Combine AI and RFID
  • High-throughput, automated phenotyping
  • Machine vision
  • PROV being filed

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AI/DIGITAL BIOTECH

A 3D Bioprinted Tissue Engineered Device for Recreating the Human Bone Marrow Niche

T19445

  • Tissue-engineered multi-physiological system of bone marrow
  • Includes vascular geometries, human hematopoietic cells, matrices that support cell polarization and differentiation, and perfusion
  • MarrowPrint biomimetic device is useful for marrow pathology, bone trauma, and the development of therapeutics for cancer and infectious diseases
  • PROV filed

Micropatterned PEG Composite Granular Hydrogels

T19450

  • Micropatterning technique to increase the porosity of hydrogels
  • Aligned pores in the hydrogel to mimic native tissues
  • Nanoporosity supports controlled release of small molecules
  • PROV filed

Predicting Pulmonary Function Abnormalities With a Texture-Based Quantification of Chest Computed Tomography

T19468

  • AI-based model predicts pulmonary function abnormalities
  • Restrictive and/or obstructive patterns are identified with texture-based convolutional neural networks quantification of normal lung index
  • Uses conventional and low-dose chest CT images
  • software

Machine-Learning-Informed Platform for Somatic Variant Classification and Pathogenicity Prediction

T19500

  • ArlVPI (Variant Pathogenecity Index) is a groundbreaking machine-learning-informed mechanistic platform designed to enhance the classification and pathogenicity assessment of somatic variants in cancer
  • PROV filed

Diffusion Tensor Imaging Neuronal Imaging Software Analysis

T19555

  • Software to analyze Diffusion Tensor Imaging (DTI) MRI scans
  • Processes data encoded in DTI scans to extract specific regions of (brain) tissue and reference against publicly available atlases
  • Can be run on local computer in minutes to hours as opposed to the currently available software that requires weeks on a supercomputer to analyze

Home-Based Quantification of Motor Symptoms in Neurological Disorders Using Visual Feedback

T19560

  • Can quantify motor dysfunction in persons with neurological disorders
  • Videos acquired with a smartphone
  • Realtime visual feedback
  • Copyrighted software, fully developed

A Method to Reduce Cybersickness in Immersive Virtual Reality

T19577

  • VR is being developed for numerous applications from gaming to training purposes
  • Cybersickness is an issue in VR applications for many people
  • UF has developed system to prevent cybersickness that prevents many from accessing VR applications

Voice Control Application

T19596

  • Records voice during different speech tasks
  • Voice tremor, voice inconsistency, speed of cognitive processing, voice speed, and voice coordination
  • Neurological disorders
  • Voice and motor problems
  • Copyrighted software, fully developed

Software for Tooth Volume Calculations

T19601

  • Tooth volume, root volume, crown-root ratio, and root surface
  • Segmented Cone Beam CT images
  • Pre-and post-treatment root volume
  • orthodontic treatment
  • Copyrighted software, fully developed

Mouse Behavioral Tracking in Y-Maze Software

T19661

  • Dual program system designed to process input videos or images for detailed mouse tracking via positional and heat map data
  • Enhances the accuracy of movement tracking and facilitates visual and statistical representations of behavioral dynamics

Automated Quantification of Fluorescently Stained Images Software

T19662

  • Custom image software to analyze fluorescently labeled brain slices
  • Automated process to locate size and shape of interest (validated on murine brain bleed model)
  • More accurate than current industry standard programs allowing for quantitative analysis

Automated Version of the Sinking Platform Test

T19719

  • an automated version of the Sinking Platform Test (SPT), a behavioral paradigm designed to measure persistence in rodents by assessing their ability to maintain goal-directed behavior despite repeated failures
  • The SPT has proven highly sensitive in detecting antidepressant effects, distinguishing chronic from acute treatments, and offering superior predictive validity compared to traditional tests like the forced swim test
  • Log data on latency, platform climbs, and search strategies, with an AI-driven behavioral analysis module identifying individual differences in persistence and stress coping
  • PROV in process

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CELL & GENE THERAPY

AAV VP3 Only Capsids for Instrument Calibration

T18857

  • Homogenous AAV1 VP3 particles for accurate calibration of mass spectrometers

AAV Capsids With Reduced Liver Tropism

T19244, T19604, T19679

  • AAV library that detargets liver
  • Tropism to CNS and/or heart
  • In vivo data demonstrating CNS targeting of specific variants

STING Targeting Gene Therapy for STING-mediated Human Illnesses

T19457

  • STING Targeting Gene Therapy
  • AAV encoding human STING AQ allele or HAQ allele
  • These alleles are resistant to STING activation-induced cell death and prevent STING inflamation in vivo
  • PROV filed

MicroUtroDysChimeras with Promoters

T19481

  • New micro-utrophin/dystrophin chimeric constructs that are optimized for skeletal and cardiac muscle and to avoid the presentation of neoantigens.
  • A chimeric micro-utrophin/dystrophin construct can be used in patients with N-terminal mutations in dystrophin, as well as other DMD patients
  • PROV filed

Oncolytic Viral Vectors Inducing Immunogenic Cell Death for Antitumor Immunotherapy

T19514

  • AAVs that express cell death executioners to lyse cancer cells and trigger antitumor immune responses
  • Drive gene expression specifically in the epithelial cells (including carcinoma cells of breast, lung, colon, prostate, pancreatic, bladder
  • AAV-infected cancer cells will express GSDMD or MLKL, undergo lytic cell death (pyroptosis or necroptosis), and release tumor antigens and immune-stimulating DAMPs (damage-associated molecular patterns), which together activate antitumor immune responses
  • PROV filed

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CNS, NEUROLOGICAL DISEASE

Brain-derived neurotrophic factor (BDNF) mouse model

S-T00358_1, S-T00358_2

  • Brain-derived neurotrophic factor (BDNF)
  • High Throughput Screening (HTS)
  • Available at Jackson Labs

Mitochondrial Neuroprotectants as Therapeutics for ALS and Other Neurodegenerative Diseases

S-T00387

  • Novel molecules that protect mitochondria, axons and dendrites
  • Improves mitochondrial health
  • Potential ALS therapeutic
  • PROV filed

Novel Dystonia Mouse Models With Overt Dystonia

T19460

  • Dystonia mouse model
  • No retarded growth
  • Available at Jackson Labs

Beta-Adrenergic Receptor Antagonists from Kava

T19467

  • Analogues of kavalactones and yangonin non-amine-based negative allosteric modulators of beta-adrenergic receptor
  • Potential treatment of psychiatric illnesses such as generalized anxiety disorder, bipolar disorder, and depression
  • PROV filed

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ENZYMES & MISCELLANEOUS

A Screening Platform for the Discovery of Molecular Glue Degraders From DNA-Encoded Libraries

S-T00395

  • System is capable of screening millions of compounds at a time for the ability to drive the Ubiquitylation of a bead-bound POI by an E3 Ub ligase
  • Discovery of monovalent molecular glue-type degraders
  • PROV filed

Haloferax Volcanii RecJ3/4-aRNaseJ and Its Subcomplexes RecJ3/4 and aRNaseJ Form New Types of Nucleases with Novel Properties

T18980

  • H. volcanii aRNase J
  • Unusually catalyzing both 3′-5′ and 5′-3′ exonuclease activities in modifying RNA and ssDNA
  • Stable in extreme conditions
  • PCT filed

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IMMUNOTHERAPY

Poly Lactide-Co-Glycolide Nanoparticle as Antibody Lyoprotectant

T19681

  • PGLA-stabilization of antibodies during lyophilization
  • Outperforms standard lyoprotectants
  • PROV in process

Suppression of Anti-Drug Antibodies by CATCH-Leupeptin Biomaterial for the Delivery of Protein Drugs

T19780

  • When taken up into antigen-presenting cells, the leupeptin attached to CATCH will inhibit proteases within endolysosomal vesicles (MHCII compartment) and prevent antigen processing, ultimately stunting the generation of antibodies against a co-delivered p
  • Eight CATCH-Leupeptin variants, showing that the inhibitory properties of leupeptin are preserved
  • Part of a series of CATCH peptides
  • CATCH = Co-Assembly Tags based on Charge complementarity
  • Multiple filings

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INFECTIOUS DISEASE

Compounds and Methods for Treating Sepsis

T18929

  • Sepsis

Seven Gene Panel for Identifying HYPO Sepsis Phenotype Patients

T19264

  • Sepsis

Outer Membrane Vesicle Vaccine to Prevent Norovirus Infection

T19413

  • Recombinant bacterial strains that express norovirus proteins on cell surface and bacterial outer membrane vessicles
  • Applications as probiotic or vaccine for norovirus
  • PROV filed

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MEDICAL DEVICES

SiCN and QSiCN as Thin-Film Anti-Bacterial Coatings for Multiple Applications

T17926, T19164

  • Silicon carbide coating
  • Antibacterial properties in dentistry
  • Secondary caries, peri-implantitis
  • Corrosion- and wear-resistant
  • US Patent 11,752,236

Systems And Methods for Capacitance-Based Measurement of Bodily Fluids

T19178, T19260, T19263

  • Automated body fluid collection
  • From the patient directly into the EHR
  • Compatible with EPIC hospital system

Silk Fibroin from Plodia Interpunctella and Methods for Creating Biomaterial Scaffolds

T19231, T19537

  • Use of pantry moth (Plodia interpunctella) considered to be an agricultural pest as “bioreactor” to produce silk fibroin for biomaterials and other applications
  • UF researchers have developed protocols to rear the pantry moth indoors with a standardized diet that does not result in variation in silk fibroin production, unlike other silk producing insects and arachnids
  • Genetic modification of insects allows for controlled alteration of silk fibroin properties

QSiCN and SiCN Coatings for Dental Applications

T19327

  • Addition of Nitrogen to dielectric Silicon Carbide thin film
  • Anti-bacterial, osseointegrative and anti-corrosive
  • Quaternization adds an additional nitrogen ion that imparts improved antibacterial properties to the coating
  • PROV filed

Veterinary Lift Laparoscopic Device Patent Disclosure

T19404

  • fits Medtronic® SurgiSleeve™ wound protectors
  • 3 sizes
  • pull up on the wound retractor and physically lift the patient’s body wall to create space
  • PROV filed

Countersink Drill Bit for Deep Brain Stimulation Surgery

T19546

  • Parkinson’s disease
  • Deep brain stimulation
  • Compatible commercial drills

A Substrate Functionalized With Antioxidant for Biological Sample Collection and Preservation

T19561

  • Functionalize dried blood-spot paper by covalently attaching ascorbic acid to the cellulose fibers that can then be used to collect and preserve dried blood spots.
  • PROV filed

High-Throughput Multi-Well Miniaturized Foam Fractionation System and Method for Efficient Separation of Surface-Active Compounds

T19648

  • Miniaturized foam fractionation into a 96-well format, providing a scalable, reproducible, and efficient solution for simultaneous analysis or enrichment of multiple samples
  • PFAS enrichment and analysis could be performed on the foam in a high throughput, environmentally-friendly, and low cost manner, avoiding other potentially contaminating devices
  • highthroughput adaptation for separating surface-active compounds using a 96-well plate format, enabling efficient, scalable, and parallelized analysis
  • PROV filed

One-shot ELISA: Streamlined Lyophilized ELISA Plate

T19688

  • Field kit ELISA
  • Lyophilized and stabilized adsorbed protein, blocking, and secondary that is rehydrated with analyte
  • 60-minute incubation time
  • PROV being filed

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MICROBIOME

GlcNAc as a Prebiotic Agent Against Multiple Oral Diseases

T19371

  • GlcNAc maintains homeostasis and remodel biofilm metabolism
  • GlcNAc as a prebiotic to control dental caries
  • GlcNAc to modulate bacterial central metabolism
  • PROV filed

Heterologous Production of Bioactive Natural Products in Native Gut and Probiotic E. coli

T19573

  • Engineered the native gut strain E. coli EcAZ-1 and the probiotic strain E. coli Nissle 1917 (EcN) to biosynthesize bioactive compounds, including the plant-derived flavonoid naringenin and mycosporine-like amino acids.
  • PROV filed

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ONCOLOGY

A Screening Platform for the Discovery of Molecular Glue Degraders From DNA-Encoded Libraries

S-T00395

  • DNA-encoded library technology for molecular glue discovery
  • Screen libraries of up to several million compounds for functionality
  • Compounds screened for ability to drive ubiquitylation of a protein of interest by an E3 Ub ligase
  • PROV filed

Bcl-xl/Bcl-2 Dual Degraders and Uses Thereof

T19430

  • Dual degraders that have been tuned as potent protein degraders and increased oral bioavailability
  • PROV filed

YAP Degrading Molecules as Potential Anticancer Drugs

T19462

  • YAP is the major downstream effector for the Hippo signaling pathway
  • YAP degraders (PROTACs) as potential cancer therapeutics
  • PROV filed

Bcl-2 Degraders

T19493

  • Potent selective degraders of Bcl-2
  • Minimal or no impact on Bcl-xL
  • 100x more potent than venetoclax
  • PROV filed

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PAIN, INFLAMMATION

Release Selective Agonists of the Mu Opioid Receptor (MOR)

S-T00400

  • Compounds selectively activate different states of  mu-opioid receptor, specifically the ability to induce GTPγS binding and GTPγS release from the G protein
  • An entirely new class of compounds with a novel mechanism at the MOR
  • Envisioned desirable benefits include lowering the required effective dose of an opioid, delaying the onset of drug tolerance, minimizing dose-limiting side effects (e.g., respiratory depression, euphoria, GI effects), or alleviating opioid withdrawal symptoms

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RNA THERAPEUTICS

mRNA delivery methods

T19644, T19079

  • Targeted in vivo RNA selective to the lungs over the liver
  • Lung tropism exhibited following IV injection
  • Delivery of mRNA to treat pulmonary disease
  • PROV in progress

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VETERINARY

Surgical Implant Device Allowing Precise and Controlled Delivery of Fluids Into the Nose

T19494

  • A surgical implant device for use in research animals, wherein a small access port is secured onto the nasal bone
  • Allows controlled delivery of fluid into the nose
  • PROV filed

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ONLINE GRADUATE PROGRAM IN PHARMACEUTICAL CHEMISTRY

Take your team’s productivity and expertise to the next level

The University of Florida College of Pharmacy’s Pharmaceutical Chemistry graduate program offers an online master’s degree and graduate certificate with a concentration in pharmaceutical chemistry.

Who is it for?

This program is offered to working professionals with an undergraduate degree and hands-on experience to deepen their knowledge in preclinical drug development.

We collaborate with industry partners to offer a relevant, flexible, and high-quality course of study. Aside from our core required courses and electives, we offer tailored course content specifically applicable to your employee’s needs.

Concurrent MBA option

Alongside our M.S. in Pharmaceutical Chemistry program, we offer a concurrent M.S./MBA program with Stetson University – ideal for cultivating potential leaders in your organization.

Core required courses

The core required courses in the program provide an overview of the entire preclinical drug development process, including in silico, in vitro, and in vivo drug development up until submission of an IND.

  • Fundamentals of Pharmaceutical Chemistry
  • Pharmaceutical Chemistry 1 & 2
  • Pharmaceutical Analysis 2
  • Laboratory Quality Assurance & Control
  • Special Topics in Pharmaceutical Chemistry (final exam)

Your employees can take advantage of rolling admissions and affordable tuition; no GRE/GMAT is required. Learn more at pharmchem.cop.ufl.edu.

Contact:

Oliver Grundmann, Ph.D., FCP
Assistant Dean of Lifelong Learning
UF Department of Medicinal Chemistry
grundman@ufl.edu

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