Kriya Highlights Positive Preclinical Data for KRIYA-586, a Gene Therapy Product Candidate for Thyroid Eye Disease (TED), at ESOPRS Annual Meeting

UF Startup Kriya Therapeutics, Inc., (Kriya), a biopharmaceutical company developing gene therapies to address common diseases affecting millions of people around the world, announced preclinical data from its gene therapy program for thyroid eye disease (TED). The data are being presented at the 42nd Annual Meeting of the European Society of Ophthalmic Plastic & Reconstructive Surgery (ESOPRS) being held September 12-14 in Rotterdam, the Netherlands.

KRIYA-586 is an investigational adeno-associated virus (AAV) gene therapy product engineered to express an antibody that inhibits Insulin-Like Growth Factor 1 Receptor (IGF1R), a key target implicated in the pathogenesis of TED. Currently, the only medicine approved in the U.S. for the treatment of TED is an intravenously infused human monoclonal antibody that blocks IGF1R. KRIYA-586 is designed for one-time delivery through a focal peribulbar injection performed in the office—with the goal of providing local and durable expression of anti-IGF1R antibody from transduced periorbital fat and muscle cells to help address the ocular manifestations of TED while minimizing systemic toxicities.