Entrinsic Bioscience Shares Breakthrough in Rehydration Technology

Groundbreaking research conducted by a team of leading researchers at Entrinsic Bioscience (EBS) and the University of Florida revealed significant findings that will change the way we understand amino acid combinations and represents the next generation of Oral Rehydration Solutions (ORS). 

Dr. Sadasivan Vidyasagar, associate professor of the Department of Radiation Oncology, University of Florida, led the team in this research. He is a founder of Entrinsic Bioscience, a UF startup and an alumnus of UF Innovate | Accelerate, and chair of the Entrinsic Scientific Advisory Board. The paper, titled “Select Amino Acids (AA-ORS) Improve Electrolyte and Fluid Absorption in a Rodent Diarrhea Model” was presented by Dr. Astrid Grosche, University of Florida, at a Plenary Session during Digestive Disease Week (May 6-9) in Chicago.

The study demonstrated that Entrinsic’s AA-ORS was superior to WHO-ORS in increasing electrolyte and fluid absorption in the presence of cholera toxin, decreasing epithelial anion channel activity and improving intestinal barrier function. This advanced ORS formulation will now undergo testing in clinical trials for validation as a new treatment option in patients with infectious diarrhea.

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