UF Researchers Demonstrate GLP-1RAs’ Potential To Treat Depression

A study led by researchers in the University of Florida College of Pharmacy has found that GLP-1RAs, a class of glucose-lowering medication, may offer antidepressant effects.

In a National Institutes of Health-funded study published in the Annals of Internal Medicine on Feb. 25, UF researchers studied Medicare claims data of older adults with Type 2 diabetes to assess their risk of depression while undergoing treatment with either GLP-1RAs, SGLT2is or DPP4is.

The 28,000 study participants were randomly assigned treatment with one of the three medications, and their health was followed for up to two years until the onset of depression symptoms or death or until they could no longer be contacted.

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