Solid Biosciences Shares Updates on Inspire Duchenne Clinical Trial of SGT-003

Solid Biosciences, a life sciences company developing precision genetic medicines for neuromuscular and cardiac diseases that acquired UF startup AavantiBio, shared updates on the INSPIRE DUCHENNE clinical trial for their next-generation AAV micro-dystrophin gene therapy candidate, SGT-003, for the treatment of Duchenne.

Based on early study results, the trial has expanded its enrollment to a total of 43 participants and broadened the age range to include individuals from 4 to less than 12 years old. Additionally, the evaluation of functional endpoints has been adjusted from 12 months to 18 months, allowing for a better assessment of SGT-003’s potential to impact disease progression. They also announced the addition of three new clinical trial sites. Data from the first three patients will be shared in early 2025.

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