Researcher Gains New Insight Into How Cells Sense, Address Protein-Building Malfunctions

Cells are constantly making new proteins based on instructions from our genes. Ribosomes, the tiny cellular machines that build those proteins, are impressively fast and accurate, but sometimes they hit a glitch.

The process of how cells sense a glitch and begin repairs so the machinery can return to its protein-building job — as well as how cells dispose of the aberrant proteins produced by the glitch — has become clearer due to the work of Scripps Florida professor Claudio Joazeiro, Ph.D., and his collaborators. The findings were published in the journal Nature on March 9.

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