Researchers’ Discovery Advances Knowledge of Key Cellular Function

The role of ribosomes in converting genetic code into protein molecules is well known. Despite that, much less is known about how ribosomes arise. More surprisingly, recent discoveries have indicated different “flavors” of ribosomes produce different proteins.

Now, researchers at Scripps Research’s Florida campus have discovered how normal ribosomes are “remodeled” into different subtypes as a response to cellular stress.

Those findings have implications for better understanding the cellular pathways and processes that lead to a genetic form of anemia and some cancers, said Katrin Karbstein, Ph.D., a professor of structural and computational biology at Scripps and lead author of a new paper published Feb. 25 in the journal Sciences Advances.

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