Genetic Mutation Could Play Role in Improving Leukemia Treatment, UF Health Researchers Find

In the battle against one type of leukemia, a genetic mutation could hold the key to more effective, lower-dose treatments. The new, early findings by University of Florida Health researchers and their colleagues are especially relevant for older or frail patients who may not be able to tolerate high-dose chemotherapy.

The findings center on acute myeloid leukemia, or AML — a blood and bone marrow cancer that is one of the most common types of leukemia. About one-fourth of AML patients carry a mutation in a gene known as DNMT3A. That mutation can make patients less responsive to certain chemotherapy treatments.

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