UF Health Researcher Helps Show Hormone Can Reverse Inflammation From Fatty Liver Disease

Pushed by the obesity epidemic, a rising number of Americans are being diagnosed with nonalcoholic fatty liver disease, a condition that can lead to liver inflammation and cirrhosis. It is now the leading cause of liver transplantation in the United States.

No drug to fight the disease has yet been approved by the U.S. Food and Drug Administration. The best way to fight this potentially deadly inflammation? Weight loss.

A new study co-authored by a University of Florida Health endocrinologist shows a hormone that affects the brain so that patients have less appetite and thereby lose weight resolved inflammation from fatty liver disease in nearly 6 out of 10 people who received the highest daily dosage in a clinical trial.

The study, co-authored by Kenneth Cusi, M.D., chief of the UF College of Medicine’s division of endocrinology, diabetes and metabolism, was published in The New England Journal of Medicine by a team of international researchers.

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