University of Florida Health researchers are gaining new insights into cells linked to a genetic mutation that causes a type of muscular dystrophy.
Using genome editing, the researchers developed mice that replicate the developmental timing of a dysfunctional gene that causes myotonic dystrophy type 1, or DM1. They then showed that two types of cells — precursor cells needed for muscle regeneration and epithelial cells in the brain that help produce cerebral spinal fluid — are particularly sensitive to the DM1 mutation.
The findings were published in the journal Genes & Development by a research team led by Maurice Swanson, Ph.D., a professor in the UF College of Medicine’s Department of Molecular Genetics and Microbiology and associate director of the UF Center for NeuroGenetics.Learn more about University of Florida Health Researchers Gain New Insight Into Muscular Dystrophy Gene. Learn more about the technology available for licensing: Dmpk CTG480 Knock-in Mouse Model for Myotonic Dystrophy Type 1.