‘Fine Tuning’ Certain Cells May Prevent Gut Inflammation, Researchers Find

Keeping the intestinal tract in balance requires a delicate dialogue between gut microbes and the body. When that gets disrupted, inflammation and intestinal damage can result.

New findings by University of Florida Health researchers and their collaborators show how certain cells in the colon can be “fine-tuned” by chemically attaching a sugar molecule to a protein. That is crucial for developing prebiotics — non-digestible food ingredients that promote the growth of beneficial gut bacteria and protect against intestinal pathogens.

The findings by Mansour Mohamadzadeh, Ph.D., a professor in the UF colleges of Medicine and Veterinary Medicine, and his collaborators were published recently in the journal Mucosal Immunology.

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