New Study Shows Modified T Cells Enhance Effectiveness of Immunotherapy in Tumors (MBI News)

New Study Shows Modified T Cells Enhance Effectiveness of Immunotherapy in Tumors

In a new cell-culture and mouse-model study, a research team at the McKnight Brain Institute led by UF’s Jianping Huang, M.D., Ph.D., and Linchun Jin, M.D., Ph.D., demonstrated a novel technique using the injection of genetically modified cells to enhance the effectiveness of immunotherapy to halt or even shrink late-stage solid tumors.

In the study, published in Nature Communications, investigators aimed to tackle the main obstacles of using chimeric antigen receptor (CAR T-cell therapy) to target large tumors such as glioblastoma, ovarian cancer or pancreatic cancer. In aggressive cancers, the ability to treat late-stage tumors that can’t be surgically removed is potentially lifesaving.

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