Oragenics, Inc. Announces Enrollment of 60th Patient in Clinical Trial (BusinessWire)

Oragenics, Inc. Announces Enrollment of 60th Patient in Clinical Trial

UF Innovate | Sid Martin Biotech resident client Oragenics, Inc., a leader in the development of new antibiotics against infectious diseases and effective treatments for oral mucositis, announced the enrollment of the 60th patient in its Phase 2 double-blind, placebo-controlled clinical trial of AG013.

AG013 is an oral mouth rinse composed of a recombinant Lactococcus lactisbacteria strain that contains the coding sequence for human trefoil family factor 1 (hTFF1), which is continually secreted by the bacteria. The trefoil factor family (TFF) is a family of three different peptides secreted by epithelial cells of the gastrointestinal tract in response to injury (Hoffman, 2004). Their presence has been implicated in reducing chemotherapy- and radiation-induced injury, both in preclinical studies (Beck et al., 2004) and in clinical trials (Peterson et al., 2009).

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