UF Brain Tumor Researcher Embarks on First-in-Human Clinical Trial of Novel Immunotherapy Vaccine (UF Health Newsroom)

UF Brain Tumor Researcher Embarks on First-in-Human Clinical Trial of Novel Immunotherapy Vaccine

UF Health pediatric oncologist Elias Sayour, M.D., Ph.D., has received a $2.5 million grant from the pediatric cancer foundation CureSearch for Children’s Cancer to undertake a first-in-human clinical trial to test a novel form of immunotherapy to treat the most aggressive forms of malignant brain tumors.

The FDA-approved clinical trial, slated to begin this summer, is the latest step in a yearslong translational-research pursuit to determine the efficacy of a new vaccine method developed in Sayour’s lab. The method has shown promise in preclinical research in mouse models and currently is being evaluated in a clinical trial involving five pet dog patients suffering from terminal brain cancer with no other treatment options, in collaboration with the UF College of Veterinary Medicine.

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