UF-Led Study Offers Insights Into Adoptive Cellular Therapy to Treat Brain Tumor (MBI)

UF-Led Study Offers Insights Into Adoptive Cellular Therapy to Treat Brain Tumor

New research led by UF’s Catherine Flores, Ph.D., and Duane Mitchell, M.D., Ph.D., offers insights to brain tumor researchers seeking to understand if certain patients are likely to respond to treatment known as adoptive cellular therapy, a type of immunotherapy in which T cells are infused into a patient to help fight cancer.

The study, published in the journal Science Advances with peers at the University of Florida, Duke University Medical Center and Stanford University Medical Center, is a significant advance, yielding data from both mouse models and a human clinical trial using a novel form of adoptive cellular therapy developed at UF.

“Brain tumor patients who receive adoptive cellular therapy may benefit from this research as this could help inform us if treated patients are responding to therapy,” said Flores, principal investigator of the Hematopoietic Stem Cell Engineering Laboratory within UF’s Preston A. Wells Jr. Center for Brain Tumor Therapy. “This study suggests that we have the potential to identify responders versus non-responders to therapy.”

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