AAK1 DEGRADERS (New Generation)
Improvement over previous inhibitors because it blocks binding of the cleaved AAK-1 to mRNA
Targeting HDAC3 and HDAC8 for the Treatment of Hematological Cancers
a method of treating a blood cancer in a human subject comprising downregulating Histone Deacetylase 3 (HDAC3) and Histone Deacetylase 8 (HDAC8), including with protein degraders
IAP-Recruiting Bcl-xL Degraders
PROTACs that used inhibitors of apoptosis as E3 ligases for degradation of Bcl-xL This may be a good combo with deoxyrubicin.
Bcl-xl/Bcl-2 Dual Inhibitors and Uses Thereof
Chaperone-mediated targeting chimeras (CMTACs) that kill Bcl-2/Bcl-xl cells through inhibition rather than degradation Data in vivo NSCLC and ALL cell line.
GRP78 Selective Inhibitors to Treat Lung and Ovarian Cancer
GRP78 inhibitors that are selective relative to the other 12 HSP70 isoforms in the human body These are dipeptides that bind to GRP78. In particular, compound 12 (B4C1) is most potent In vivo data in lung cancer, and also data in ovarian cancer
Novel Cereblon Modulators
Cereblon is a protein-encoding gene that acts as a substrate receptor for the CRL4 E3 ubiquitin ligase complex. Novel complexes.
Compositions and Methods to Induce Exercise-Like Metabolic Adaptation for Long-Term Health
Identification of compounds found in plasma that mimic exercise Conveys the benefits of exercise without exercising
Peripheral Dopamine Signaling as a Druggable Exercise-Mimetic Target for Lung Cancer
Identification of compounds found in plasma that mimic exercise Conveys the benefits of exercise without exercising