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GRP78 Selective Inhibitors to Treat Lung and Ovarian Cancer

  • GRP78 inhibitors that are selective relative to the other 12 HSP70 isoforms in the human body
  • These are dipeptides that bind to GRP78. In particular, compound 12 (B4C1) is most potent
  • In vivo data in lung cancer, and also data in ovarian cancer
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