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New RNA-Based “Light Switch” Technology Could Speed Disease Testing (UF News)

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Researchers at the University of Florida have unveiled an affordable new technique that can spot single-letter genetic mutations in minutes, which could improve infectious disease testing, cancer genotyping and personalized medicine.

The new system, called FARSIGHT, acts like a programmable molecular “light switch.” When FARSIGHT encounters a perfectly matched genetic sequence, it folds into a fluorescent structure and lights up. Even a one-nucleotide mismatch, which is the smallest possible genetic letter difference, prevents activation.

 

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