Edwardsiella Piscicida: A Vaccine Delivery Platform for Multiple Fish Pathogens
A vaccine vector based on a bacterial pathogen that infects a wide variety of fresh and saltwater fish species Enables delivery of vaccines to mucosal-associated lymphoid tissue (e.g., by immersion) Can be used to deliver both subunit as well as DNA vaccines
Protective Immunity Enhanced Attenuated Salmonella Vaccine (PIESV) Vector Systems
Enhanced Salmonella vaccine vectors for both antigen and DNA vaccine delivery with enhanced recruitment of innate immunity and maximal induction of protective acquired immunity This vector system has been developed, tested and refined over 30 years and can be used to vaccine (via mucosal surfaces) against a wide variety of bird and animal diseases
Live Self-Destructing Attenuated Adjuvant Salmonella (AAS) Strains to Maximize Innate Immunity
A universal adjuvant strain that can be easily delivered to mucosal surfaces (orally, or nasally) to stimulate innate immunity and induce low level protective immunity In one example, chicks can be immunized in ovo to protect them from wide variety of bacterial and viral pathogens Replace use of growth enhancing antibiotics in the feed
Feline Immunodeficiency Virus (FIV) Vaccine
Developing and testing a vaccine that protects cats from all subtypes of feline immunodeficiency virus (FIV) Evolutionarily conserved epitopes between the FIV subtypes, as well as HIV, have been identified which are used in a multi-antigenic peptide and an adjuvant that induces a T-cell response
FCoVs and SARS-CoV-2 Vaccines and Diagnostics
A vaccine for dogs and cats to generate sterilizing immunity against canine and feline coronaviruses (CoVs) Prevents shedding of virus particles and spread of disease; dogs and cats do not develop serious symptoms
Invasion Protein G as a Salmonella Vaccine and Diagnostic Marker
A subunit vaccine for poultry that controls Salmonella colonization of laying hens Antibodies against the same protein can be used as a diagnostic for Salmonella in eggs