Precision Medicine: Targeting the Human Gut Microbiota With Bacteriophages as a Management Strategy for Neurodegenerative Diseases
protein folding homeostasis upon intestinal colonization bacteria disrupt the protein-folding environment and contribute to the pathogenesis of neurodegenerative diseases by inducing toxic protein aggregation employ bacteriophages to remove the detrimental bacteria from the host gut
Microbiota Gene Manipulation Through Exosome-Mediated siRNA
Method of using siRNA to knockdown target gene expression in bacterial cells siRNA sequences and processing machinery are delivered to prokaryotic cells using mammalian extracellular vesicles Knockdown of both endogenous and exogenous genes has been demonstrated in vitro
Tailoring Probiotic Strains to Human Genotype for Increased Probiotic Efficacy
The protective HLA haplotype of a subject affects the efficacy of probiotics Methods for predicting probiotic efficacy for disease conditions such as UC, IBS and Crohn’s disease based on HLA haplotyping
Lactobacillus Johnsonii N6.2 Alleviates Diabetes Type 2 Symptoms
These strains delay the onset of T2D and reduce the severity or progression of T2D Capsule delivery method protects bacteria for release at the duodenum. Other formulations available Significant decrease in fasting glucose, AUC, kidney nephropathy, and insulitis in a mouse model Strains show efficacy in T1D