UF Researchers Find Gene Mutation Involved in Cancer Progression
University of Florida researchers have found mutation hot spots in a unique class of proteins that could drive cancer progression. “There are recurrent mutations that are associated with cancer development,” said Jonathan Licht, M.D., director of the UF Health Cancer Center and study co-author. “Many of these mutations inactivate the functions of important proteins that […]
UF-Led Study Offers Insights Into Adoptive Cellular Therapy to Treat Brain Tumor
New research led by UF’s Catherine Flores, Ph.D., and Duane Mitchell, M.D., Ph.D., offers insights to brain tumor researchers seeking to understand if certain patients are likely to respond to treatment known as adoptive cellular therapy, a type of immunotherapy in which T cells are infused into a patient to help fight cancer. The study, […]
Study Helps Hepatitis C Patients, Shows Path for Accelerating Research and Potential for Drug Approvals
In a new kind of real-world study, a “pragmatic” clinical trial, UF researchers found that hepatitis C patients who previously did not respond to oral drug therapy were cured by a recently approved drug regimen. The study, published in the journal Gastroenterology’s December issue (available online) showed that the fixed-dose combination of glecaprevir/pibrentasvir, marketed as […]
Immunomic Therapeutics’ Collaborator, a University of Florida Researcher, Presents New Clinical Data at the 2019 Society for Neuro-Oncology (SNO) Annual Meeting
Immunomic Therapeutics, Inc., a privately-held clinical-stage biotechnology company pioneering the study of nucleic acid immunotherapy platforms, announced that Duane Mitchell, MD, Ph.D., a University of Florida professor of neurosurgery and co-director of the Preston A. Wells Jr. Center for Brain Tumor Therapy and his team, will present new clinical data at the 2019 Society for […]
Have Hope: Discover Treatment Options for Pancreatic Cancer
Pancreatic cancer affects more than 42,000 Americans each year and is the fourth leading cause of cancer-related death in the United States. This Pancreatic Cancer Awareness Month, patients should know of the treatments available at UF Health. With several different approaches available, the treatment of pancreatic cancer is determined by the type and staging, which […]
New Test Can Better Predict Long-Term Death Risk After Heart Valve Procedure
A simple test done during a minimally invasive heart valve replacement can predict a patient’s long-term risk of death, a group led by a University of Florida Health researcher has found. The test involves pressure measurements within the heart following a transcatheter aortic valve replacement or TAVR. The highly specialized procedure involves repairing a failing […]
University of Florida Health Researchers Gain New Insight Into Muscular Dystrophy Gene
University of Florida Health researchers are gaining new insights into cells linked to a genetic mutation that causes a type of muscular dystrophy. Using genome editing, the researchers developed mice that replicate the developmental timing of a dysfunctional gene that causes myotonic dystrophy type 1, or DM1. They then showed that two types of cells […]
‘Fine Tuning’ Certain Cells May Prevent Gut Inflammation, Researchers Find
Keeping the intestinal tract in balance requires a delicate dialogue between gut microbes and the body. When that gets disrupted, inflammation and intestinal damage can result. New findings by University of Florida Health researchers and their collaborators show how certain cells in the colon can be “fine-tuned” by chemically attaching a sugar molecule to a […]
UF Health Researchers Launch Trial Involving Gut Bacteria’s Role in Type 1 Diabetes
Graciela Lorca, Ph.D., was part of a University of Florida Health research team that discovered about a decade ago that something was amiss in the guts of diabetic rats. Their intestinal tracts, which like humans are teaming with billions of microorganisms that aid digestion, had fewer numbers of a particular probiotic compared with the guts […]
Age of Woman’s First Menstruation May Signal Higher Risk of Heart Disease, UF Health Research Finds
It might seem like an irrelevant question for a cardiologist to ask a female patient, but University of Florida Health researcher Carl J. Pepine, M.D., hopes it will one day become as routine as asking someone if they smoke or have high blood pressure. Women who experienced their first menstruation at an early or late […]