Climbing a New Path Allows Chemists To Ascend Cancer’s Steepest Research Challenges

The cancer gene MYC has been called the “Mount Everest” of cancer research because of the difficulty of designing medications that can disable it, and the expectation that an effective MYC drug could help so many cancer patients. A collaboration among RNA scientists, chemists and cancer biologists in Florida and Germany has climbed that peak, while opening new routes to summit other similarly hard-to-treat diseases.

New Scientist Takes Aim at TB, the World’s Deadliest Infectious Disease

Luiz Pedro Carvalho, Ph.D., is on a quest to find new medicines for treatment-resistant diseases, including tuberculosis, which is again the world’s deadliest infectious disease, after briefly falling behind COVID-19. Carvalho is the newest faculty member to join The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology as a professor of chemistry.

RNA Symposium Attracts Thought Leaders in Basic and Translational Research to Jupiter, FL

More than 175 people attended “RNA: From Biology to Drug Discovery” at The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology. It was the first major scientific conference at the institute since the pandemic began, and so researchers relished the opportunity to share recent work and reconnect. The conference attracted 18 impressive outside speakers, including multiple Howard Hughes Medical Institute investigators, members of the U.S. National Academy of Sciences and the Institute of Medicine. Incoming Max Planck President-Elect Patrick Cramer, Ph.D., shared his structural studies of the machinery underlying DNA transcription, featuring riveting imaging of transcription complexes in motion.

Jupiter Scientist Courtney Miller Named BioFlorida’s Entrepreneur of the Year

Praising her ongoing passion for developing a new class of treatments for cancer and addiction, Florida’s biotechnology industry organization, BioFlorida, has awarded its 2022 Weaver H. Gaines Entrepreneur of the Year award to Courtney Miller, Ph.D., director of academic affairs and a professor at UF Scripps Biomedical Research in Jupiter, Florida.

Novel Target Discovered for Potentially Treating and Preventing Osteoarthritis

Scientists at UF Scripps Biomedical Research have described a specific protein that manages activities within chondrocytes, a critical cell type that maintains healthy cartilage in joints. As people age and stress their joints, their chondrocytes begin to fail. The UF Scripps team found that activating a specific protein in these cells called RORβ (beta) could restore multiple factors needed for smooth joints to healthier levels, helping to control inflammation.