University of Florida
University of Florida

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Using Lair 1 Blockade for Cancer Immunotherapy (As Mono or Combination Therapy)

  • Method of treating checkpoint inhibitor blockade therapy resistant cancer, such as GBM, with an anti-LAIR-1 antibody
  • LAIR-1 is strongly associated with negative immune checkpoints in GBM
  • Administration of anti-LAIR-1 antibody reversed myeloid-derived suppressor cell mediated T-cell suppression in vivo
  • Anti-LAIR-1 antibody treatment in a PD-1 blockage-resistant GBM mouse model, showed positive outcomes both alone and in combination with CAR-T therapy. Including synergistic effects with anti-LAIR-1 and CAR-T therapy, reduced tumor growth and increased survival time
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