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Targeted Degradation of the Oncogenic microRNA 17–92 Cluster by Structure-Targeting Ligands

  • A specific dimer  to target three miRNAs in the cluster, miR-17, miR-18a, and miR-20a, to inhibit their biogenesis
  • Direct cleavage by  recruiting an endogenous nuclease, or a ribonuclease targeting chimera (RIBOTAC)
  • The compound selectively reduced levels  in  polycystic kidney disease, prostate cancer, and breast cancer
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