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Modified Arrestin-1 to Enhance Photoreceptor Survival in Retinal Disease

Modified Arrestin-1 delivered to retina with AAV
Modified Arrestin-1 binds enolcase-1 without reducing inhibitory effect of enolase-1, an advantage over native protein
Slows retinal degeneration, slows loss of photoreceptor ERG function, improves photoreceptor survival
Murine model of retinitis pigmentosa

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