University of Florida
University of Florida

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METTL3/METTL14 Degraders

  • The bifunctional molecules are optimized to bind both METTL3/METTL14 and a ubiquitin E3 ligase (e.g., VHL and CRBN), recruiting the E3 ligase to the vicinity of METTL3/METTL14 for polyubiquitination and subsequent proteasomal degradation.
  • PROV filed 1-2024
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