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Kappa and Mu Opioid Agonists and Antagonists

  • Kappa opioid agonists for pain, itch, and anxiety without side effects (sedation, dysphoria, diuresis. In vivo testing of target. DMPK studies ongoing. (S-T00362) and a new class (PROV filed 10-2023) with EC50, EMAX in 2-3 assays, microsomal stability stu
  • Novel selective MOR agonists, MOR antagonists, KOR agonists, and KOR antagonists based on natural product GB18. In vivo work ongoing. PCT filed 1-2023. (S-T00364)
  • KOR Effectors (S-T00141) and MOR agonists (S-T00134, S-T00190)
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