Immunotherapy – UF Innovate https://innovate.research.ufl.edu Building business on innovation Tue, 04 Mar 2025 02:07:58 +0000 en-US hourly 1 https://wordpress.org/?v=6.9.4 https://innovate.research.ufl.edu/wp-content/uploads/favicon-blue_1.png Immunotherapy – UF Innovate https://innovate.research.ufl.edu 32 32 Using Lair 1 Blockade for Cancer Immunotherapy (As Mono or Combination Therapy) https://innovate.research.ufl.edu/tech-bio/using-lair-1-blockade-for-cancer-immunotherapy-as-mono-or-combination-therapy/ Tue, 04 Mar 2025 02:07:58 +0000 https://scaddev1.com/?post_type=tech-bio&p=2947
  • Method of treating checkpoint inhibitor blockade therapy resistant cancer, such as GBM, with an anti-LAIR-1 antibody
  • LAIR-1 is strongly associated with negative immune checkpoints in GBM
  • Administration of anti-LAIR-1 antibody reversed myeloid-derived suppressor cell mediated T-cell suppression in vivo
  • Anti-LAIR-1 antibody treatment in a PD-1 blockage-resistant GBM mouse model, showed positive outcomes both alone and in combination with CAR-T therapy. Including synergistic effects with anti-LAIR-1 and CAR-T therapy, reduced tumor growth and increased survival time
    • ]]>         Bacterial Vesicle (BV) for Ex Vivo Priming of NK Cells for Use in Adoptive Transfer and As In Situ Vaccination (ISV) https://innovate.research.ufl.edu/tech-bio/bacterial-vesicle-bv-for-ex-vivo-priming-of-nk-cells-for-use-in-adoptive-transfer-and-as-in-situ-vaccination-isv/ Tue, 04 Mar 2025 02:07:38 +0000 https://scaddev1.com/?post_type=tech-bio&p=2945
  • Bacterial extracellular vesicles from gram-negative bacteria are introduced to NK cells to activate them for use in chemotherapy
    • ]]>         Fibroblast Growth Factor 7 Peptide (FGF7-P) https://innovate.research.ufl.edu/tech-bio/fibroblast-growth-factor-7-peptide-fgf7-p/ Tue, 04 Mar 2025 02:07:18 +0000 https://scaddev1.com/?post_type=tech-bio&p=2943
  • Blocks cyclophosphamide inducing apoptosis in urothelial tissue in cancer patients
  • Repairs cyclophosphamide damaged urothelial tissue
  • Equal strength as full length FGF7
  • Longer shelf life compared to full length FGF7
  • Cheaper to synthesize than full length FGF7
    • ]]>         Disease-Specific Antibodies https://innovate.research.ufl.edu/tech-bio/disease-specific-antibodies/ Tue, 04 Mar 2025 02:06:57 +0000 https://scaddev1.com/?post_type=tech-bio&p=2941
  • S-T00345: “Rabbit Monoclonal Antibodies Targeting Multiple Myeloma Cell Surface Antigens”
  • S-T00363: “Rabbit Monoclonal Antibodies Targeting Acute Myeloid Leukemia Antigens”
  • S-T00319: “Singlec-6 Antibodies, Derivatives Molecules and Related Uses”
  • S-T00191: ROR2 antibody compositions
    • ]]>         Improved Salmonella Vectored Therapies for Treatment of Cancer https://innovate.research.ufl.edu/tech-bio/improved-salmonella-vectored-therapies-for-treatment-of-cancer/ Tue, 04 Mar 2025 02:06:36 +0000 https://scaddev1.com/?post_type=tech-bio&p=2939
  • Salmonella has the ability to regress tumors because of its natural toxicity and can also be used as a vector to deliver other anti-cancer molecules including cytotoxic agents
  • Created a genetically modified Salmonella cell that encodes a gene product to target a specific cancer cell and a second gene product that kills the target cell following internalization
  • Demonstrated POC with a mouse model of bladder cancer
    • ]]>         Genetically Encoded Safety Switch for Transplanted Stem Cell-Derived Cells https://innovate.research.ufl.edu/tech-bio/genetically-encoded-safety-switch-for-transplanted-stem-cell-derived-cells/ Tue, 04 Mar 2025 02:06:14 +0000 https://scaddev1.com/?post_type=tech-bio&p=2937
  • A safety switch to remove unwanted cells
  • Engineers a stem cell or T cell with a surface protein (CAR antigen or other cell surface reporter/molecule) so that the cell can be switched off in the case of cancer or viral infection
    • ]]>