Using Lair 1 Blockade for Cancer Immunotherapy (As Mono or Combination Therapy)
Method of treating checkpoint inhibitor blockade therapy resistant cancer, such as GBM, with an anti-LAIR-1 antibody LAIR-1 is strongly associated with negative immune checkpoints in GBM Administration of anti-LAIR-1 antibody reversed myeloid-derived suppressor cell mediated T-cell suppression in vivo Anti-LAIR-1 antibody treatment in a PD-1 blockage-resistant GBM mouse model, showed positive outcomes both alone and […]
Bacterial Vesicle (BV) for Ex Vivo Priming of NK Cells for Use in Adoptive Transfer and As In Situ Vaccination (ISV)
Bacterial extracellular vesicles from gram-negative bacteria are introduced to NK cells to activate them for use in chemotherapy
Fibroblast Growth Factor 7 Peptide (FGF7-P)
Blocks cyclophosphamide inducing apoptosis in urothelial tissue in cancer patients Repairs cyclophosphamide damaged urothelial tissue Equal strength as full length FGF7 Longer shelf life compared to full length FGF7 Cheaper to synthesize than full length FGF7
Disease-Specific Antibodies
S-T00345: “Rabbit Monoclonal Antibodies Targeting Multiple Myeloma Cell Surface Antigens” S-T00363: “Rabbit Monoclonal Antibodies Targeting Acute Myeloid Leukemia Antigens” S-T00319: “Singlec-6 Antibodies, Derivatives Molecules and Related Uses” S-T00191: ROR2 antibody compositions
Improved Salmonella Vectored Therapies for Treatment of Cancer
Salmonella has the ability to regress tumors because of its natural toxicity and can also be used as a vector to deliver other anti-cancer molecules including cytotoxic agents Created a genetically modified Salmonella cell that encodes a gene product to target a specific cancer cell and a second gene product that kills the target cell […]
Genetically Encoded Safety Switch for Transplanted Stem Cell-Derived Cells
A safety switch to remove unwanted cells Engineers a stem cell or T cell with a surface protein (CAR antigen or other cell surface reporter/molecule) so that the cell can be switched off in the case of cancer or viral infection