Bacterial Strains as Probiotics to Prevent Neurodevelopmental Disorders
Equol-producing bacteria Autism spectrum disorder up to 19 years old Infant gut microbiome associated with later-diagnosed neurodevelopmental disorders
Circular Bifunctional Aptamers With Enhanced Blood-Brain-Barrier (BBB) Penetration for Tauopathy Therapy and Imaging Diagnostics
Enhance in vivo BBB penetration for improved therapy
Injectable Thermally Gelling Hydrogel Formulations of Decellularized Porcine Peripheral Nerves
Provides biologically and clinically relevant scaffold and signals for nerve survival and regeneration Many porcine products have been approved for human use by the FDA Promotes Schwann cell survival in inflammatory model system May be combined with other treatments
ALS Therapeutic
~40 analogues made and under evaluation Increases mitochondrial function, length, and number
Novel Mouse Model to Study Brain-Derived Neurotrophic Factor-Related Diseases (Huntington, Alzheimer’s, Parkinson’s)
Transgenic mouse model using nano luciferase BDNF diseases can be studied using this model High throughput in vitro screening assay with transgenic BDNF cells for drug selection
Microbe-Free Capsular Polysaccharide as a Formulation for Drug Delivery Into the Central Nervous System
Glucorunoxylomannan is used to make the blood-brain barrier temporarily permeable for drug delivery
Treatment of Repeat Expansion Protein Associated Diseases (ALS, FLD, Friedreich’s Ataxia)
Small Molecule Inhibitors to treat neurological diseases (motor neuron disease) Small Molecule Inhibitors to treat diseases with repeat-associated non-AUG proteins (RAN proteins)
Metabolically Stable Sigma Receptor Ligands
Sigma receptors are highly expressed in CNS and targets for psychostimulant Antagonist sigma receptor compounds with long-lasting analgesic effect Metabolic stability, binding affinity, in vivo studies
Novel Synthetic ERR Agonists II
High-affinity ERR Agonists Effective in models of heart failure, metabolic disease, and cognitive dysfunction