REV-ERB Antagonists
Lead compounds increase lean mass, improve muscle function, improve muscle pathology, and reduce fibrosis in dystrophic muscle Novel structure with three leads Potencies in 10nM range, good preliminary PK CTX mouse model
Natural Product Combinations REV-ERB Ligands
Exercise mimetic Reduce fat in muscle tissue
Non-Caloric Carbohydrates To Improve Cognition
Specialized carbohydrates that enhance neuronal connectivity and plasticity by influencing neurotransmitter synthesis Modulate ECM components, resulting in improved cellular communication, reduced inflammation, and restoration of the BBB