arthritis – UF Innovate https://innovate.research.ufl.edu Building business on innovation Tue, 12 Aug 2025 04:33:39 +0000 en-US hourly 1 https://wordpress.org/?v=6.9.4 https://innovate.research.ufl.edu/wp-content/uploads/favicon-blue_1.png arthritis – UF Innovate https://innovate.research.ufl.edu 32 32 Novel Target Discovered for Potentially Treating and Preventing Osteoarthritis https://innovate.research.ufl.edu/novel-target-discovered-for-potentially-treating-and-preventing-osteoarthritis/ Mon, 17 Oct 2022 00:00:00 +0000 https://scaddev1.com/novel-target-discovered-for-potentially-treating-and-preventing-osteoarthritis/ Scientists at UF Scripps Biomedical Research have described a specific protein that manages activities within chondrocytes, a critical cell type that maintains healthy cartilage in joints. As people age and stress their joints, their chondrocytes begin to fail. The UF Scripps team found that activating a specific protein in these cells called RORβ (beta) could restore multiple factors needed for smooth joints to healthier levels, helping to control inflammation.

Activating RORβ could serve as a new approach to prevent or delay development of the osteoarthritis, according to the researchers who published their study “RORβ modulates a gene program that is protective against articular cartilage damage” in PLOS.

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